|
KMID : 1123920100240050822
|
|
Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 5 p.822 ~ p.826
|
|
|
Effects of Faeces Trogopterori on the Production of Chemokine in HUVECs
|
|
Moon Chang-Min
Kwon Kang-Beom
Ryu Do-Gon
|
|
|
Abstract
|
|
|
|
In order to validate the use of Faeces Trogopterori as an anti-inflammatory drug in the traditional Korean medicine, I have investigated the effect of water-soluble extract of F. Trogopterori (EFT) on the production of monocyte chemoattractant protein-1 (MCP-1), of which chemokine stimulates the migration of mononuclear cells, in human umbilical vein endothelial cells (HUVECs) stimulated with tumor necrosis factor-alpha. The extract inhibited dose-dependently MCP-1 production without its cytotoxic effect on HUVECs, as measured by enzyme-linked immunosorbent assay, and significantly decreased mRNA levels of MCP-1, as determined using reverse transcription polymerase chain reaction. These results suggest that F. Trogopterori may have therapeutic potential in the control of endothelial disorders caused by inflammation.
|
|
|
KEYWORD
|
|
|
extract of Faeces Trogopterori(EFT), human umbilical vein endothelial cells, macrophage chemoattractant protein-1
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|